Rationale for Therapeutic Drug Monitoring of Biopharmaceuticals in Inflammatory Diseases
نویسندگان
چکیده
منابع مشابه
Practical recommendations for the use of therapeutic drug monitoring of biopharmaceuticals in inflammatory diseases
Biopharmaceuticals directed against tumor necrosis factor-alpha, integrins, interleukins, interferons and their receptors have become key agents for the management of inflammatory diseases in the fields of gastroenterology, rheumatology, dermatology and neurology. However, response to these treatments is far from optimal. Therapeutic failure has been attributed in part to inadequate serum conce...
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PURPOSE OF REVIEW There are an expanding number of therapies available to treat pediatric inflammatory bowel disease (IBD). As pediatric gastroenterologists attempt to achieve complete intestinal mucosal healing for their patients, it has become more important to gain an understanding of how to maximize the efficacy of our medications while minimizing their toxicities. We aim to provide an over...
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BACKGROUND Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive factors of loss of response (LOR) to adalimumab using TDM in IBD patients. METHODS One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, m...
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ژورنال
عنوان ژورنال: Therapeutic Drug Monitoring
سال: 2017
ISSN: 0163-4356
DOI: 10.1097/ftd.0000000000000410